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Mean baseline ldl-c was 341 mg dl in those patients randomized to atorvastatin 80 mg or simvastatin 80 mg alone and 316 mg dl in the group randomized to zetia plus atorvastatin 40 or 80 mg or simvastatin 40 or 80 mg.

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The degree of increase in ezetimibe exposure may be greater in patients with severe renal insufficiencyIn patients treated with cyclosporinethe potential effects of the increased exposure to ezetimibe from concomitant use should be carefully weighed against the benefits of alterations in lipid levels provided by ezetimibe.

The most frequently reported side effects were upper respiratory tract infectiondiarrheaarthralgiasinusitisand pain in extremityRef]

From this studyit may be concluded that addition of ezetimibe has incremental effects on LDL cholesterol reductionIn patients with a high risk of hepatic insufficiencythe addition of ezetimibe to the lowest dose of lovastatin may be helpful in preventing adverse effects of high-dose lovastatin while gaining the full benefits of high-dose lovastatinAlsothe combination of ezetimibe and lovastatin has no greater adverse effects than lovastatin monotherapy7

There are no adequate and well-controlled studies of ezetimibe in pregnant womenEzetimibe should be used during pregnancy only if the potential benefit justifies the risk to the fetus.

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