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Generic Nametacrolimusoral and injectionta KROE li musBrand NamesAstagraf XLEnvarsus XRHecoriaPrograf.
This drug passes into breast milk and the effect on a nursing infant is unknownDiscuss the risks and benefits with your doctor before breast-feeding.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administrationwhenever solution and container permit.
The use of Prograf in liver transplant recipients experiencing post-transplant hepatic impairment may be associated with increased risk of developing renal insufficiency related to high whole-blood concentrations of tacrolimusThese patients should be monitored closely and dosage adjustments should be consideredSome evidence suggests that lower doses should be used in these patientssee Dosage In Adult KidneyLiverOr Heart Transplant PatientsUse in Specific Populations and CLINICAL PHARMACOLOGY
Monitoring of tacrolimus blood concentrations in conjunction with other laboratory and clinical parameters is considered an essential aid to patient management for the evaluation of rejectiontoxicitydose adjustments and complianceObserved whole blood trough concentrations can be found in Table 1Factors influencing frequency of monitoring include but are not limited to hepatic or renal dysfunctionthe addition or discontinuation of potentially interacting drugs and the post-transplant timeBlood concentration monitoring is not a replacement for renal and liver function monitoring and tissue biopsiesData from clinical trials show that tacrolimus whole blood concentrations were most variable during the first week post-transplantation.
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