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Treatment with SARAFEM and any concomitant serotonergic agentsshould be discontinued immediately if the above events occur and supportive symptomatic treatment should be initiated.
The half-life of concurrently administered diazepam may be prolonged in some patientssee CLINICAL PHARMACOLOGYCoadministration of alprazolam and fluoxetine has resulted in increased alprazolam plasma concentrations and in further psychomotor performance decrement due to increased alprazolam levels.
Renal impairmentUse cautiondrug accumulation may occur with severe renal impairment.
Fluoxetine may cause a condition that affects the heart rhythmQT prolongationQT prolongation can rarely cause seriousrarely fatalfast/irregular heartbeat and other symptomssuch as severe dizzinessfaintingthat need medical attention right away.
AGenerally acceptableControlled studies in pregnant women show no evidence of fetal risk.
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