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Before starting a long-term treatmentboth eyes should be carefully examined for visual acuitycentral visual fieldand color visionExamination should also include fundoscopyThese examinations should be repeated at least annuallyRetinal toxicity is largely dose-related.

Do not dispose of medications in wastewatere.gdown the sink or in the toiletor in household garbageAsk your pharmacist how to dispose of medications that are no longer needed or have expired.

Retinopathy may progress even after the drug is discontinuedIn a number of patientsearly retinopathymacular pigmentation sometimes with central field defectsdiminished or regressed completely after therapy was discontinuedIf allowed to developthere may be a risk of progression even after treatment withdrawalParacentral scotoma to red targetssometimes calledpremaculopathyis indicative of early retinal dysfunction which is usually reversible with cessation of therapy.

Check with your doctor as soon as possible if any of the following side effects occur:

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call your doctor immediately or get emergency medical help if you experience any of the following serious side effects any vision problems, such as reading difficulties, sensitivity to light, seeing light flashes or streaks, blurred distance vision, or other issues hearing problems, such as ringing or ticking in the ears, or hearing changes plaquenil may have toxic effects on your inner ear loss of balance, coordination, room spinning, or other vertigo symptoms muscle weakness bleeding or bruising of the skin irregular heartbeat mood or mental changes, such as confusion or other changes in thinking, feelings, or behavior bleaching or loss of hair drowsiness convulsions.

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