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Low corticosteroid levelsadrenal insufficiencycertain types of arthritis allergic conditions multiple sclerosis lupus and other collagen diseases other diseases affecting the lungsskineyeskidneysbloodthyroidstomachand intestines.
As with any printed referencethe use of particular drugsregimens and drug dosages may become out-of-date over timesince new information may have been published and become generally accepted after the latest update to this printed informationPlease keep in mind that health care professionals are fully responsible for practicing within current standardsavoiding use of outdated regimensemploying good clinical judgment in selecting drugs and/or regimensin calculating doses for individual patientsand verifying all dosage calculations.
The diurnal rhythm of the HPA axis is lost in Cushing’s diseasea syndrome of adrenocortical hyperfunction characterized by obesity with centripetal fat distributionthinning of the skin with easy bruisabilitymuscle wasting with weaknesshypertensionlatent diabetesosteoporosiselectrolyte imbalanceetcThe same clinical findings of hyperadrenocorticism may be noted during long-term pharmacologic dose corticoid therapy administered in conventional daily divided dosesIt would appearthenthat a disturbance in the diurnal cycle with maintenance of elevated corticoid values during the night may play a significant role in the development of undesirable corticoid effectsEscape from these constantly elevated plasma levels for even short periods of time may be instrumental in protecting against undesirable pharmacologic effects.
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