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13There is an increase in the risk of gallbladder disease in women receiving HRTsee Conditions that need supervision

If you are taking the extended-release tabletsdo not crushchewor dissolve themDoing so can release all of the drug at onceincreasing the risk of side effectsAlsodo not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do soSwallow the whole or split tablet without crushing or chewing.

Additional postmarketing adverse reactions have been reported in patients receiving other forms of hormone therapy.

There is no evidence from randomised controlled trials of protection against myocardial infarction in women with or without existing CAD who received combined estrogen-progestogen or estrogen-only HRTRandomised controlled data found no increased risk of CAD in hysterectomised women using estrogen-only therapy.

Cases of anaphylaxiswhich develop within minutes to hours after taking orally-administered PREMARIN and require emergency managementhave been reported in the postmarketing settingSkinhivespruritusswollen lips-tongue-faceand either respiratory tractrespiratory compromiseor gastrointestinal tractabdominal painvomitinginvolvement has been noted.

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premarin is a drug derived from pregnant mares urine pmu , is prescribed for symptoms of menopause .

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