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Prior to initiating treatment with PROSCARconsideration should be given to other urological conditions that may cause similar symptomsIn additionprostate cancer and BPH may coexistPatients with large residual urinary volume and/or severely diminished urinary flow should be carefully monitored for obstructive uropathyThese patients may not be candidates for finasteride therapy.

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In patients with chronic renal impairmentwhose creatinine clearance ranged from 9-55 ml/minthe disposition of a single dose of 14 C-finasteride was not different from that in healthy volunteersProtein binding also did not differ in patients with renal impairmentA portion of the metabolites which normally is excreted renally was excreted in the faecesIt therefore appears that faecal excretion increases commensurate to the decrease in urinary excretion of metabolitesDosage adjustment in non-dialysed patients with renal impairment is not necessary.

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