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Although indinavir cannot eliminate hiv already present in the body, it can reduce.

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1General Common side effects that have been reported by some indinavir users can include nauseavomitingabdominal or flank painheadachediarrheafatigue or weaknessand difficulty falling asleep.

Midazolam is extensively metabolized by CYP3A4Co-administration with CRIXIVAN with or without ritonavir may cause a large increase in the concentration of this benzodiazepineNo drug interaction study has been performed for the co-administration of CRIXIVAN with benzodiazepinesBased on data from other CYP3A4 inhibitorsplasma concentrations of midazolam are expected to be significantly higher when midazolam is given orallyTherefore CRIXIVAN should not be co-administered with orally administered midazolamsee CONTRAINDICATIONSwhereas caution should be used with coadministration of CRIXIVAN and parenteral midazolamData from concomitant use of parenteral midazolam with other protease inhibitors suggest a possible 3-4 fold increase in midazolam plasma levelsIf CRIXIVAN with or without ritonavir is co-administered with parenteral midazolamit should be done in a setting which ensures close clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedationDosage reduction for midazolam should be consideredespecially if more than a single dose of midazolam is administered.

Keep all appointments with your doctor and the laboratoryYour doctor will order certain lab tests to check your response to indinavir.

Concomitant use of CRIXIVAN and StJohn’s wortHypericum perforatumor products containing StJohn’s wort is not recommendedCoadministration of CRIXIVAN and StJohn’s wort has been shown to substantially decrease indinavir concentrationssee CLINICAL PHARMACOLOGYDRUG INTERACTIONSand may lead to loss of virologic response and possible resistance to CRIXIVAN or to the class of protease inhibitors.

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a lipodystrophy syndrome has been commonly reported with indinavir and other protease inhibitors combined with nrtis, but it has also been reported in many protease inhibitor-naive patients, and a definitive causal link has not been established between the syndrome and protease inhibitors.

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