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Amenorrhea associated with decreased estrogen and increased gonadotropin secretion develops in a significant proportion of women treated with cyclophosphamideAffected patients generally resume regular menses within a few months after cessation of therapyGirls treated with cyclophosphamide during prepubescence generally develop secondary sexual characteristics normally and have regular mensesOvarian fibrosis with apparently complete loss of germ cells after prolonged cyclophosphamide treatment in late prepubescence has been reportedGirls treated with cyclophosphamide during prepubescence subsequently have conceived.

500 mg vial contains 534.5 mg cyclophosphamide monohydrate equivalent to 500 mg cyclophosphamide and 375 mg mannitol 1 g vial contains 1069.0 mg cyclophosphamide monohydrate equivalent to 1 g cyclophosphamide and 750 mg mannitol 2 g vial contains 2138.0 mg cyclophosphamide monohydrate equivalent to 2 g cyclophosphamide and 1500 mg mannitol.

InfectionsThe following manifestations have been associated with myelosuppression and immunosuppression caused by cyclophosphamideincreased risk for and severity of pneumoniasincluding fatal outcomesother bacterialfungalviralprotozoal andparasitic infectionsreactivation of latent infectionsincluding viral hepatitistuberculosisPneumocystis jiroveciherpes zosterStrongyloidessepsis and septic shock.

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