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1997 , double-blind comparison of olanzapine versus risperidone in the treatment of schizophrenia and other psychotic disorders.

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During pregnancyuse olanzapine with caution if benefits outweigh risksAnimal studies show risk and human studies not available or neither animal nor human studies doneNeonates exposed to antipsychotic drugs during 3rd trimester of pregnancy are at risk for extrapyramidal symptomsEPSor withdrawal symptoms after deliverythese complications vary in severitywith some being self-limited and others requiring ICU support and prolonged hospitalization.

The following findings are based on premarketing trials of1oral olanzapine for schizophreniabipolar I disordermanic or mixed episodesa subsequent trial of patients having various psychiatric symptoms in association with Alzheimer’s diseaseand premarketing combination trialsand2intramuscular olanzapine for injection in agitated patients with schizophrenia or bipolar I mania.

Drug Reaction with Eosinophilia and Systemic SymptomsDRESSreported with olanzapine exposureDRESS may present with a cutaneous reactionsuch as rash or exfoliative dermatitiseosinophiliafeverand/or lymphadenopathy with systemic complications such as hepatitisnephritispneumonitismyocarditisand/or pericarditisDRESS is sometimes fataldiscontinue olanzapine if DRESS suspected.

5-10 mg per day initiallyif necessarymay be titrated upward in increments of 5 mg per day at intervals greater than 1 week Maintenance10-20 mg per daynot to exceed 20 mg per day.

Use in combination with fluoxetine 5 mg in eveningadjusted to range of 5-12.5 mg/daymay be increased up to 20 mg/day in resistant depression.

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all the trial patients received ranitidine as well as olanzapine, and the control patients received placebo with olanzapine for 16 weeks.

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