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A few cases of reversible clinical hepatotoxicity have been noted in patients taking Zyloprimand in some patientsasymptomatic rises in serum alkaline phosphatase or serum transaminase have been observedIf anorexiaweight lossor pruritus develop in patients on Zyloprimevaluation of liver function should be part of their diagnostic workupIn patients with pre-existing liver diseaseperiodic liver function tests are recommended during the early stages of therapy.

APseudogout is a form of arthritis that is brought on by deposits of calcium crystals in the jointsThis causes painswelling and inflammation of the jointand sometimes may be accompanied by feverIt is not always clear why people develop pseudogoutRisk factors may includeagejoint injuryand genetic disordersfamilial chondrocalcinosis and hemochromatosisSome of the treatments that may be used for pseudogout includeNon-steroidal anti-inflammatoriesNSAIDsoral steroidsinjectable steroidsand also colchicineColchicine may be used to prevent attacks of pseudogoutHowever it does not appear that colchicine is FDA-approved for this indicationAllopurinol is in a group of medications called xanthine oxidase inhibitorsAllopurinol is used to prevent the buildup of uric acid crystals that lead to painful gout and kidney stonesAllopurinol works by inhibiting the enzyme that converts hypoxanthine to xanthine and xanthine to uric acidThere was no mention of allopurinol being used in the treatment of pseudogout or preventing buildup of calcium crystalsFor more specific informationconsult with your doctor for guidance based on your health status and current medicationsparticularly before taking any actionKristen DorePharmD.

The prothrombin time should be reassessed periodically in the patients receiving dicumarol who are given Zyloprim.

To make sure you can safely take Zyloprimtell your doctor if you have any of these other conditions:

A few cases of reversible clinical hepatotoxicity have been noted in patients taking Zyloprimand in some patientsasymptomatic rises in serum alkaline phosphatase or serum transaminase have been observedIf anorexiaweight lossor pruritus develop in patients on Zyloprimevaluation of liver function should be part of their diagnostic workupIn patients with pre-existing liver diseaseperiodic liver function tests are recommended during the early stages of therapy.

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