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Areas not suitable for injection are those that are anatomically inaccessible such as spinal joints and those like the sacroiliac jointswhich are devoid of synovial spaceTreatment failures are most frequently the result of failure to enter the synovial spaceIf failures occur when injections into the synovial spaces are certainas determined by aspiration of fluidrepeated injections are usually futileLocal therapy does not alter the underlying disease processand whenever possible comprehensive therapy including physiotherapy and orthopedic correction should be employed.

Musculoskeletal Conditions As with other adrenal steroidsDEPO-MEDROL Sterile Aqueous Suspension has been found useful in alleviating the pain and lameness associated with acute localized arthritic conditions and generalized arthritic conditionsIt has been used successfully to treat rheumatoid arthritistraumatic arthritisosteoarthritisperiostitistendinitissynovitistenosynovitisbursitisand myositis of horsestraumatic arthritisosteoarthritisand generalized arthritic conditions of dogsRemission of musculoskeletal conditions may be permanentor symptoms may recurdepending on the cause and extent of structural degeneration.

PRECAUTIONS DEPO-MEDROL Sterile Aqueous Suspension exerts an inhibitory influence on the mechanisms and the tissue changes associated with inflammationVascular permeability is decreasedexudation diminishedand migration of the inflammatory cells markedly inhibitedIn additionsystemic manifestations such as fever and signs of toxemia may also be suppressedWhile certain aspects of this alteration of the inflammatory reaction may be beneficialthe suppression of inflammation may mask the signs of infection and tend to facilitate spread of microorganismsHenceall patients receiving this drug should be watched for evidence of intercurrent infectionShould infection occurit must be brought under control by the use of appropriate antibacterial measuresor administration of this preparation should be discontinuedHoweverin infections characterized by overwhelming toxicitymethylprednisolone acetate therapy in conjunction with appropriate antibacterial therapy is effective in reducing mortality and morbidityWithout conjoint use of an antibiotic to which the invader-organism is sensitiveinjudicious use of the adrenal hormones in animals with infections can be hazardousAs with other corticoidscontinued or prolonged use is discouraged.

NoteThis document contains side effect information about methylprednisoloneSome of the dosage forms listed on this page may not apply to the brand name Medrol.

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