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Combivir , retrovir , trizivir zidovudine or azt videx or videx ec didanosine adriamycin , rubex doxorubicin copegus , rebetol , ribasphere , ribavirin , virazole ribavirin roferon-a , intron-a , and others interferon hydrea , droxia hydroxyurea .

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Pancreatitishepatotoxicityand peripheral neuropathy have occurred when hydroxyurea was administered concomitantly with antiretroviral drugsincluding didanosine and stavudinesee DRUG INTERACTIONS

HYDREA may cause macrocytosiswhich is self-limitingand is often seen early in the course of treatmentThe morphologic change resembles pernicious anemiabut is not related to vitamin B12 or folic acid deficiencyThis may mask the diagnosis of pernicious anemiaProphylactic administration of folic acid is recommended.

DisclaimerHealthline has made every effort to make certain that all information is factually correctcomprehensiveand up-to-dateHoweverthis article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professionalYou should always consult your doctor or other healthcare professional before taking any medicationThe drug information contained herein is subject to change and is not intended to cover all possible usesdirectionsprecautionswarningsdrug interactionsallergic reactionsor adverse effectsThe absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safeeffectiveor appropriate for all patients or all specific uses.

Hydroxyurea oral capsule can interact with other medicationsvitaminsor herbs you may be takingAn interaction is when a substance changes the way a drug worksThis can be harmful or prevent the drug from working well.

Three mechanisms of action have been postulated for the increased effectiveness of concomitant use of hydroxyurea therapy with irradiation on squamous cellepidermoidcarcinomas of the head and neckIn vitro studies utilizing Chinese hamster cells suggest that hydroxyurea1is lethal to normally radioresistant S-stage cellsand2holds other cells of the cell cycle in the G1 or pre-DNA synthesis stage where they are most susceptible to the effects of irradiationThe third mechanism of action has been theorized on the basis of in vitro studies of HeLa cellsIt appears that hydroxyureaby inhibition of DNA synthesishinders the normal repair process of cells damaged but not killed by irradiationthereby decreasing their survival rateRNA and protein syntheses have shown no alteration.

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i m not saying that if you are on hydrea you will be plagued with every side effect on the long list, but many people do not even realize that it comes with a slew of side effects.

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