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Carbidopa inhibits decarboxylation of peripheral levodopaIt does not cross the blood-brain barrier and does not affect the metabolism of levodopa within the central nervous system.

Levodopa is a metabolic precursor of dopamine or a compound that participates in the chemical reaction that produces dopaminewhich is able to cross the blood-brain barrier and reach the brainwhere it can be converted to dopamine.

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without food the sinemet carbidopa and levodopa might not be absorbed as well depending on the types and amounts of certain amino acids.

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