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This medication may not work right awayYou may see some benefit within a weekHoweverit may take up to 4 weeks before you feel the full effect.
Antidepressant medications are used to treat a variety of conditionsincluding depression and other mental/mood disordersThese medications can help prevent suicidal thoughts/attempts and provide other important benefitsHoweverstudies have shown that a small number of peopleespecially people younger than 25who take antidepressants for any condition may experience worsening depressionother mental/mood symptomsor suicidal thoughts/attemptsThereforeit is very important to talk with the doctor about the risks and benefits of antidepressant medicationespecially for people younger than 25even if treatment is not for a mental/mood conditionTell the doctor right away if you notice worsening depression/other psychiatric conditionsunusual behavior changesincluding possible suicidal thoughts/attemptsor other mental/mood changesincluding new/worsening anxietypanic attackstrouble sleepingirritabilityhostile/angry feelingsimpulsive actionssevere restlessnessvery rapid speechBe especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
Amitriptyline HCl is supplied as 10 mg25 mg50 mg75 mg100 mg or 150 mg tabletsEach tablet contains the following inactive ingredientscolloidal silicon dioxidehypromelloselactose monohydratemagnesium stearatemicrocrystalline cellulosepolyethylene glycolpolysorbatesodium starch glycolate and titanium dioxideThe 10 mg tablets also contain FD&C blue1 lakeThe 25 mg tablets also contain D&C yellow10 lake and FD&C blue2 lakeThe 50 mg tablets also contain synthetic black iron oxidesynthetic red iron oxide and synthetic yellow iron oxideThe 75 mg tablets also contain FD&C yellow6 lakeThe 100 mg tablets also contain D&C red33 lake and FD&C red40 lakeThe 150 mg tablets also contain FD&C blue2 lake and FD&C yellow6 lake.
Because of the wide variation in the absorption and distribution of tricyclic antidepressants in body fluidsit is difficult to directly correlate plasma levels and therapeutic effectHoweverdetermination of plasma levels may be useful in identifying patients who appear to have toxic effects and may have excessively high levelsor those in whom lack of absorption or noncompliance is suspectedBecause of increased intestinal transit time and decreased hepatic metabolism in elderly patientsplasma levels are generally higher for a given oral dose of amitriptyline hydrochloride than in younger patients.
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