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Although clinical studies have shown that CRESTOR alone does not reduce basal plasma cortisol concentration or impair adrenal reservecaution should be exercised if CRESTOR is administered concomitantly with drugs that may decrease the levels or activity of endogenous steroid hormones such as ketoconazolespironolactoneand cimetidine.

Patients should be instructed not to take 2 doses of CRESTOR within 12 hours of each other.

Research has found that most side effects of statins are related to the dose patients takeThe higher the dosethe greater the risk of certain side effects.

Advise women not to breastfeed during treatment with CRESTORsee CONTRAINDICATIONS and Use in Specific Populations

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