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Exposure to AIIRA therapy during the second and third trimesters is known to induce human fetotoxicitydecreased renal functionoligohydramniosskull ossification retardationand neonatal toxicityrenal failurehypotensionhyperkalaemiasee also section 5.3

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As a consequence of inhibiting the renin-angiotensin systemchanges in renal function including renal failure have been reportedin particularin patients whose renal function is dependent on the reninangiotensin-aldosterone system such as those with severe cardiac insufficiency or pre-existing renal dysfunctionAs with other medicinal products that affect the renin-angiotensin-aldosterone systemincreases in blood urea and serum creatinine have also been reported in patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidneythese changes in renal function may be reversible upon discontinuation of therapyLosartan should be used with caution in patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney.

Do not use Cozaar if you are pregnantIf you become pregnantstop taking this medicine and tell your doctor right awayLosartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

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