-retreatment with peginterferon alfa-2b copegus 200 mg oral tablet of prior treatment failures 48 weeks, regardless of hcv genotype.
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Genotype 1 patients who were treated with the a 48 week regimen of Pegasys and 1000-1200 Copegus had higher sustained virological response rates compared to those treated with the 24 week lower Copegus dose regimen.
Ribavirin can temporarily weaken the bone marrowUse of the anti-HIV drug AZT may make this worse.
We found that nonresponders to at least 24 weeks of conventional IFN and ribavirin combination therapy achieved 26of SVR when retreated with peginterferon alfa-2a40KDplus ribavirin for 48 weeksThis result is higher than previously reported resultsOn the other handour results on relapsersSVR of 51are quite similar to what was reported by Herrine et al937 to 45Probablythe more advanced histological disease observed among HALT-C patients contributed to lowering the rates of SVR observed by Shiffman et al10Howeverone has to consider that the conventional interferon normally used in the Brazilian public health services comes from various countrieswith no prospective and controlled evaluation of virological responsesObservational studies have suggested that virological responses could be inferior to those obtained in the registration trials reported by some investigators11,12This should bring the issue that Brazilian nonresponders may be an easier group to be retreated compared to non Brazilian patientssince there is a lack of quality assurance in the first antiviral therapy in Brazil.
Hep C treatment can cure a person from Hep CHoweverbeing cured of Hep C does not protect you from being reinfected in the future.
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