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In addition, there was no effect upon clindamycin sulfoxide formation following incubations with heat-inactivated microsomes compared with control microsomes fig.

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Clindamycin can cause diarrheawhich may be severe or lead to seriouslife-threatening intestinal problemsIf you have diarrhea that is watery or bloodystop using this medicine and call your doctor.

Cdifficile produces toxins A and Bwhich contribute to the development of CDADHypertoxin producing strains of Cdifficile cause increased morbidity and mortalityas these infections can be refractory to antimicrobial therapy and may require colectomyCDAD must be considered in all patients who present with diarrhea following antibiotic useCareful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.

Clindamycin comes as a capsule and a solutionliquidto take by mouthIt is usually taken three to four times a dayThe length of your treatment depends on the type of infection you have and how well you respond to the medicationTake clindamycin at around the same times every dayFollow the directions on your prescription label carefullyand ask your doctor or pharmacist to explain any part you do not understandTake clindamycin exactly as directedDo not take more or less of it or take it more often than prescribed by your doctor.

Parenteral product contains benzyl alcoholwhich has been associated with gasping syndrome and death in newborns.

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6 times the highest recommended adult human dose based on mg m , respectively or subcutaneous doses of clindamycin up to 250 mg kg day 1.

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