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Metoclopramide should not be used in epileptics or patients receiving other drugs which are likely to cause extrapyramidal reactionssince the frequency and severity of seizures or extrapyramidal reactions may be increased.
Restlessnessdrowsinessfatigueand lassitude may occur in patients receiving the recommended prescribed dosage of Reglan InjectionInsomniaheadacheconfusiondizzinessor mental depression with suicidal ideation also may occursee WARNINGSIn cancer chemotherapy patients being treated with 1-2 mg/kg per doseincidence of drowsiness is about 70There are isolated reports of convulsive seizures without clear-cut relationship to metoclopramideRarelyhallucinations have been reported.
Giving a promotility drug such as metoclopramide theoretically could put increased pressure on suture lines following a gut anastomosis or closureThis possibility should be considered and weighed when deciding whether to use metoclopramide or nasogastric suction in the prevention of postoperative nausea and vomiting.
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