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Cyclophosphamide is excreted in breast milkBecause of the potential for serious adverse reactions and the potential for tumorigenicity shown for cyclophosphamide in humansa decision should be made whether to discontinue nursing or to discontinue the drugtaking into account the importance of the drug to the mother.
Cyclophosphamide is biotransformed principally in the liver to active alkylating metabolites by a mixed function microsomal oxidase systemThese metabolites interfere with the growth of susceptible rapidly proliferating malignant cellsThe mechanism of action is thought to involve cross-linking of tumor cell DNA.
Treatment with cyclophosphamide may cause significant suppression of immune responsesSerioussometimes fatalinfections may develop in severely immunosuppressed patientsCyclophosphamide treatment may not be indicatedor should be interruptedor the dose reducedin patients who have or who develop viralbacterialfungalprotozoanor helminthic infections.
What are possible late side effects of treatment with cyclophosphamideWith the use of this drugthere is risk of developing side effects months or years after treatment has been completedIn rare instancesa secondary malignancy may occur as a result of receiving this drugA secondary malignancy is a new and unrelated cancer that occurs in an individual as a result of previous treatment with radiation or chemotherapyPatients should ask their physician about the possibility of developing a secondary malignancy as a result of their treatment.
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