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Choe et al2015High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neuronsAutophagy 85 549 PMID25619659.
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Contraindications and precautions Contraindicated in patients hypersensitive to drug and patients with anuriahepatic comaor severe electrolyte depletionContraindicated if increased azotemiaoliguriaor progressive renal disease occur during therapyUse cautiously in pregnant womenpatients with sulfa allergyand in those with hepatic cirrhosis.
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