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Cases have been reported of an interaction between citalopram and clozapinewhich may increase the risk of adverse events associated with clozapineThe nature of this interaction has not been fully elucidated.

Clozaril is used to treat severe schizophreniaor to reduce the risk of suicidal behavior in people with schizophrenia or similar disorders.

Owing to its anti-alpha-adrenergic propertiesClozaril may reduce the blood-pressure-increasing effect of norepinephrine or other predominantly alpha-adrenergic agents and reverse the pressor effect of epinephrine.

Atypical antipsychotic drugsincluding Clozarilhave been associated with metabolic changes that may increase cardiovascular/cerebrovascular riskThese metabolic changes may include hyperglycaemiadyslipidemiaand body weight gainWhile atypical antipsychotic drugs may produce some metabolic changeseach drug in the class has its own specific profile.

As with other antipsychoticscaution is advised in patients with known cardiovascular disease or family history of QT prolongation

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in one case, a generic formulation of clozapine manufactured by creighton products corporation formerly a subsidiary generic house of sandoz pharmaceuticals was found to be bioequivalent to clozaril .

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