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Treatment of a chloroquine overdose must be started quicklyYou may be told to induce vomiting right awayat homebefore transport to an emergency roomAsk the poison control center how to induce vomiting in the case of an overdose.

A number of fatalities have been reported following the accidental ingestion of chloroquinesometimes in relatively small doses0.75 g or 1 g chloroquine phosphate in one 3-year-old childPatients should be strongly warned to keep this drug out of the reach of children because they are especially sensitive to the 4-aminoquinoline compounds.

This medication may cause blurred vision and may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be alert and able to see clearly.

Chloroquine causes a toxic myopathy but also produces a toxic neuropathyChloroquine is an antimalarial drug also used for the treatment of severe rheumatoid arthritissystemic lupus erythematosusand other dermatological diseasesThe clinical features of chloroquineinduced neuropathy are those of symmetrical sensorimotor polyneuropathyBoth axonal damage and primary demyelination have been reportedA prominent pathological feature of chloroquine neuropathy is ultrastructural intracytoplasmatic lamellar inclusionsresembling those described in amiodarone neuropathywithin Schwann cells and in perineurial and endothelial cells but not in axonsOnly long-term treatment has been associated with chloroquine neuropathyfollowed by complete recovery after drug withdrawal.

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